Respiratory melancholy resulting in arrest, coma, and Dying has happened with using codeine antitussives in youthful small children, specifically while in the underneath-just one-yr infants whose power to deactivate the drug isn't absolutely formulated.

Promethazine/phenylephrine/codeine is usually utilized to lower coughing, nasal congestion, together with other indications from allergy symptoms or widespread cold.

Usage of opioids, like codeine, at an early age may add to the event of problematic material use later in life.

In case you pass up a dose, skip the skipped dose and only take the subsequent dose at your typical time. Don't choose double or additional doses.

If you're taking codeine as well as excessive acetaminophen and acetylsalicylic acid (that happen to be often coupled with codeine), it may lead to liver toxicity and gastrointestinal bleeding. These serious clinical disorders can cause the subsequent indicators:

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Antihistamines and codeine are the two contraindicated to be used within the therapy of reduce respiratory tract indicators, which include bronchial asthma.

When you're having this medication, it is especially essential that the healthcare Specialist know For anyone who is taking any of the medicines outlined down below. The next interactions happen to be selected on the basis in their opportunity significance and they are not always all-inclusive.

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常見之不良反應有：瘙癢、噁心、嘔吐、昏睡、口乾、瞳孔縮小、姿態性低血壓（orthostatic hypotension）、小便不暢、便秘。

These kids could possibly be notably sensitive for the respiratory depressant effects of codeine that has been quickly metabolized to morphine. Codeine is contraindicated for publish-operative discomfort management in these people (see WARNINGS – Dying Connected to Ultra-Rapid Metabolism of Codeine to Morphine and CONTRAINDICATIONS). Excessively massive dosages of antihistamines, such as promethazine hydrochloride, in pediatric patients may well induce unexpected death (see OVERDOSAGE). Hallucinations and convulsions have happened with therapeutic doses and overdoses of promethazine hydrochloride in pediatric people. In pediatric sufferers that are acutely unwell linked to dehydration, There's an elevated susceptibility to dystonias with the usage of promethazine HCl.

Nursing moms taking codeine can also have higher morphine levels within their breast milk When they are ultra-immediate metabolizers. These increased amounts of morphine in breast milk could bring about existence-threatening or fatal Unwanted effects in nursing infants. Instruct nursing moms to Look ahead to indications of morphine toxicity in their infants which include elevated sleepiness (in excess of standard), issues breastfeeding, breathing difficulties, or limpness.

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